The radicular cysts are the most common odontogenic cysts affecting jaws. Paresthesia is rarely seen and associated with paresthesia is usually associated with the pressure of enlarged endodontic lesions on the mandibular nerve. This case report presents a radicular cyst in a 22-year-old healthy female patient and the treatment based on a review of the literature. The radiography showed a large radiolucency with a radiopaque margin involving the apices of the mandibular right second and third molars. The patient’s complaint of paresthesia disappeared after the endodontic treatment. The patient’s 4-year follow-up showed satisfactory healing with no clinical symptoms, and recovery of the periapical bone bone was observed.
Keywords: Nonsurgical endodontic treatment, Paresthesia, Radicular cyst, Large periradicular lesion.