Aim: To investigate the association between postoperative pain intensity and single nucleotide polymorphisms in SCN9A, SCN10A and SCN11A genes.
Methodology: Ninety-five patients were included in the study. All the participants recorded their preoperative percussion pain levels and preoperative pain levels on a VAS before the root canal treatment. After the treatment, a form including VAS was given to the patients to record their pain values and use of analgesic on the 1st, 2nd, 3rd and 7th days after the treatment. The DNA isolation and genotyping were performed and the association between the polymorphism and postoperative pain level was investigated.
Results: AA genotype in the SNP rs6746030 and CC genotype in the rs4286289 of the SCN9A gene were significantly associated with higher postoperative pain levels. CC genotype for SNP rs6801957 in the SCN10A gene was significantly associated with less postoperative pain.
Conclusion: The rs6746030 and rs4286289 in the SCN9A gene and SNP rs6801957 in the SCN10A gene were associated with the pain level after endodontic treatment.