Effect of single nucleotide polymorphism in the SCN9A, SCN10A, and SCN11A genes on postoperative pain

Purpose: To investigate the association between postoperative pain intensity and single nucleotide polymorphisms (SNPs) in the SCN9A, SCN10A, and SCN11A genes.
Methods: Ninety-five patients were included in the study. All the participants recorded their preoperative percussion and preoperative pain levels on a visual analog scale (VAS) before root canal treatment. After the treatment, a form including the VAS was given to the patients to record their pain values and use of analgesics on the 1st, 2nd, 3rd, and 7th days after the treatment. DNA isolation and genotyping were performed and the association between polymorphisms and postoperative pain level was investigated.
Results: The AA genotype at the SNP rs6746030 and the CC genotype at rs4286289 of the SCN9A gene were significantly associated with higher postoperative pain levels. The CC genotype at SNP rs6801957 in the SCN10A gene was significantly associated with less postoperative pain.
Conclusion: The rs6746030 and rs4286289 SNPs in the SCN9A gene and rs6801957 in the SCN10A gene were associated with pain level after endodontic treatment.